Improved synthesis of N-alkyl substituted dithieno [3, 2-b: 2′, 3′-d] pyrroles

…, W Vanormelingen, W Dehaen, T Verbiest, A Persoons…

Index: Koeckelberghs, Guy; De Cremer, Lieven; Vanormelingen, Wouter; Dehaen, Wim; Verbiest, Thierry; Persoons, Andre; Samyn, Celest Tetrahedron, 2005 , vol. 61, # 3 p. 687 - 691

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Citation Number: 66

Abstract

A new, convergent and improved synthetic method to prepare N-alkyl substituted dithienopyrroles is described. The procedure consists of a Pd-catalyzed amination of 3, 3′- dibromo-2, 2′-bithiophene. The reaction conditions were optimized, which makes this method applicable to prepare these molecules easily in high yields and on a large scale.