Canadian Journal of Chemistry

The synthesis of two phenacetin metabolites

A Focella, P Heslin, S Teitel

Index: Focella,A. et al. Canadian Journal of Chemistry, 1972 , vol. 50, p. 2025 - 2030

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Citation Number: 41

Abstract

A new metabolite of phenacetin was identified as 4-hydroxy-3-methylthioacetanilide (11). The synthesis of 11 and the isomeric 4-hydroxy-2-methylthioacetanilide (4) as well as that of the previously reported phenacetin metabolite 3-[(5-acetamido-2-hydroxyphenyl) thio] alanine (18) is described.