Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene

TA Grese, S Cho, DR Finley, AG Godfrey…

Index: Journal of Medicinal Chemistry, , vol. 40, # 2 p. 146 - 167

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Citation Number: 195

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Several methods for the synthesis of 2-aryl-3-aroylbenzothiophenes have previously been described. 11,14 The Friedel−Crafts acylation of a 2-arylbenzothiophene 2 with ...