Tetrahedron letters

Vitamin D C-22 aldehydes. New key intermediates for the synthesis of side chain modified vitamin D analogues

…, KL Perlman, RR Sicinski, ME Phelps, HK Schnoes…

Index: Kutner; Perlman; Sicinski; Phelps; Schnoes; DeLuca Tetrahedron Letters, 1987 , vol. 28, # 49 p. 6129 - 6132

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Citation Number: 15

Abstract

Abstract Vitamin D C-22 aldehyde and 1α-hydroxyvitamin D C-22 aldehyde were efficiently synthesized starting from the readily available 22, 23-bisnorcholenic acid. The usefulness of the compounds as common intermediates for the synthesis of side chain modified analogues of vitamins D2 and D3 has been demonstrated.

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