Synthetic communications

Synthesis of Anthracyclinone Precursor: 5, 12??Dihydroxy??1, 3, 4??trihydronaphthacene??2, 6, 11??quinone

G Tririya, M Zanger

Index: Tririya, Gasirat; Zanger, Murray Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059

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Citation Number: 11

Abstract

Abstract Two practical and efficient approaches for preparing large quantities of 5, 12?? dihydroxy??1, 3, 4??trihydronaphthacene??2, 6, 11??quinone 9 are described. Both synthetic approaches involve a simple route with a fewer number of steps and utilize readily available and inexpensive starting materials. Large??scale production of this precursor may prove to be useful for further research involving the synthesis of antineoplastic anthracyclines and ...