Noncryogenic Preparation of Functionalized Arylboronic Esters through a Magnesium− Iodine Exchange with in Situ Quench

…, V Blandin, J Einhorn, PY Chavant

Index: Demory, Emilien; Blandin, Veronique; Einhorn, Jacques; Chavant, Pierre Y. Organic Process Research and Development, 2011 , vol. 15, # 3 p. 710 - 716

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Citation Number: 18

Abstract

ABSTRACT: Various functionalized aryl boronic esters derived from hexylene glycol and pinacol were prepared in excellent yields according to a simple, safe procedure. The metal- halogen exchange reaction between iPrMgCl 3 LiCl and aryl iodides is performed at 0 C in the presence of a cyclic borate ester (MPBOiPr or PinBOiPr); the organomagnesium intermediate is immediately trapped in situ so that no accumulation of hazardous reactive ...