Amidino benzimidazole inhibitors of bacterial two-component systems

MA Weidner-Wells, KA Ohemeng, VN Nguyen…

Index: Weidner-Wells, Michele A.; Ohemeng, Kwasi A.; Nguyen, Van N.; Fraga-Spano, Stephanie; Macielag, Mark J.; Werblood, Harvey M.; Foleno, Barbara D.; Webb, Glenda C.; Barrett, John F.; Hlasta, Dennis J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 12 p. 1545 - 1548

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Citation Number: 104

Abstract

Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two- component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms. The moiety at the 2- position of the benzimidazole was extensively modified. In addition, the regioisomeric benzoxazoles, heterocyclic replacements for the benzimidazole, have been synthesized ...