NMR investigations on. sigma. adducts of heterocyclic compounds. 32. Telesubstitutions in heterocyclic systems. 17. Naphthyridines. 15. Occurrence of even …

HJW Van den Haak…

Index: Haak, Henk J. W. van den; Plas, Henk C. van der Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1673 - 1677

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Citation Number: 8

Abstract

It has been reported4i5 that 8-chloro-1, 7-naphthyridine (1) when reacted with potassium amide in liquid ammonia (KNH2/NH3) undergoes a teleamination, leading to 2-amino-l, 7- naphthyridine (4). As an even number of positions lies between the position of attack of the nucleophile and the position of departure of the leaving group, this reaction can be classified as an euen telesubstitution. Odd telesubstitutions are also described, as exemplified by ...