Metal-halogen exchange between polybromoanisoles and aliphatic Grignard reagents: a synthesis of cyclopenta [b] benzofurans

H Nishiyama, K Isaka, K Itoh, K Ohno…

Index: Nishiyama, Hisao; Isaka, Kojun; Itoh, Kenji; Ohno, Kiyotaka; Nagase, Hiroshi; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 407 - 410

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Citation Number: 46

Abstract

their strong basicity and* ucleophilicity can cause problems, eg, multiple metal-halogen exchanges with polyhalogenated aromatic compounds, alkylation of the aromatic ring. We were therefore interested in the possibility that metal-halogen exchange between polybromoanisoles and alkyl Grignard reagents could be employed as a mild method for generating halogenated aromatic Grignard reagents. 2