Salicylate–urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities

…, HJ Tsai, K Nishi, BD Hammock, C Morisseau

Index: Kasagami, Takeo; Kim, In-Hae; Tsai, Hsing-Ju; Nishi, Kosuke; Hammock, Bruce D.; Morisseau, Christophe Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1784 - 1789

Full Text: HTML

Citation Number: 27

Abstract

We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.

Related Articles:

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

[Kang, Dong Wook; Kim, Yong Soo; Lim, Kwang Su; Kim, Myeong Seop; Pearce, Larry V.; Pavlyukovets, Vladimir A.; Tao, Andy K.; Lang-Kuhs, Krystle A.; Blumberg, Peter M.; Lee, Jeewoo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8092 - 8105]

Development of a novel oxidatively removable and recyclable linker for combinatorial solid phase synthesis

[Li, Wen-Ren; Hsu, Nai-Mu; Chou, Hsueh-Hsuan; Lin, Sung Tsai; Lin, Yu-Sheng Chemical Communications, 2000 , # 5 p. 401 - 402]

Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection

[Venugopala, K. Narayanaswamy; Prasanna, Renuka T.; Odhav, Bharti Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8685 - 8689]

More Articles...