Synthetic neuromuscular??and ganglion??blocking agents. N??Alkylated bipyridyls, bipiperidyls, and their methylene and ethylene “homologues”

HC Beyerman, JS Bontekoe

Index: Beyerman; Bontekoe Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1395,1406

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Citation Number: 22

Abstract

Abstract The synthesis is reported of NN′-alkylated α, α′-, β, β′ and γ, γ′-bipyridylium diiodides (Type I), and of N, N′-alkylated α, α′-, β, β′-and γ, γ′-bipiperidylium diiodides (Type II) listed in Table I. It was found that when the bipyridyls were hydrogenated in absolute methanolic or ethanolic solution in the presence of a nickel catalyst not only reduction of the pyridine rings took place, but also N-alkylation by the alcohols. This nickel ...