Synthetic Communications®

Simple and efficient synthesis of belinostat

L Yang, X Xue, Y Zhang

Index: Yang, Lei; Xue, Xiaowen; Zhang, Yihua Synthetic Communications, 2010 , vol. 40, # 17 p. 2520 - 2524

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Citation Number: 7

Abstract

A novel synthesis of belinostat (1) starting from 3-nitrobenzaldehyde has been developed. The key step in this sequence involves the conversion of (2E)-3-(3-aminophenyl) acrylic acid methyl ester to (2E)-3-(3-chlorosulfonylphenyl) acrylic acid methyl ester via diazotization and sulfonylation.