Tetrahedron Letters

Microwave promoted one-pot synthesis of 2-aryl substituted 1, 3, 4-oxadiazoles and 1, 2, 4-oxadiazole derivatives using Al 3+-K10 clay as a heterogeneous catalyst

D Suresh, K Kanagaraj, K Pitchumani

Index: Suresh, Dhanusu; Kanagaraj, Kuppusamy; Pitchumani, Kasi Tetrahedron Letters, 2014 , vol. 55, # 27 p. 3678 - 3682

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Citation Number: 9

Abstract

Abstract An efficient, inexpensive method is developed for the one-pot synthesis of 2-aryl substituted 1, 3, 4-oxadiazoles and 1, 2, 4-oxadiazoles starting from acid hydrazides and trimethyl orthoformate under solvent-free, microwave conditions using a reusable Al 3+-K10 montmorillonite clay as a heterogeneous catalyst. The novelty of the present study lies in the synthesis of oxadiazole and benzimidazole moieties in a one-pot process in high yield ...