Discovery of carboranes as inducers of 20S proteasome activity

HS Ban, H Minegishi, K Shimizu, M Maruyama…

Index: Ban, Hyun Seung; Minegishi, Hidemitsu; Shimizu, Kazuki; Maruyama, Minako; Yasui, Yuka; Nakamura, Hiroyuki ChemMedChem, 2010 , vol. 5, # 8 p. 1236 - 1241

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Citation Number: 14

Abstract

In eukaryotes, proteasomes play a critical role in the degradation of most intracellular proteins.[1–4] Degradation by ubiquitin-proteasome pathway controls many fundamental cellular functions. These include cell differentiation, cell-cycle regulation, signal transduction pathways, antigen processing in immune responses, stress signaling, inflammatory responses, and apoptosis. The first step in the pathway is activation of ubiquitin-activating ...

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