3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors

CZ Ding, JT Hunt, C Ricca, V Manne

Index: Ding, Charles Z.; Hunt, John T.; Ricca, Carol; Manne, Veeraswamy Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 3 p. 273 - 275

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Citation Number: 23

Abstract

Mutated ras oncogenes are frequently found in many human cancers, most notably cancers of the pancreas (90%), colon (50%) and lung (30%). 1, 2, 3, 4, 5 and 6 The p21 Ras oncogenic products are synthesized as cytosolic proteins, which undergo post-translational modifications before assuming their proliferative functions. The first and obligatory step is farnesylation. The enzyme farnesyltransferase (FT) catalyzes this reaction. 2, 3, 4, 5, 6, 7, 8 and 9 ...