Synthesis and CHK1 inhibitory potency of hymenialdisine analogues

…, A Pierré, J Hickman, P Gloanec, G De Nanteuil

Index: Parmentier, Jean-Gilles; Portevin, Bernard; Golsteyn, Roy M.; Pierre, Alain; Hickman, John; Gloanec, Philippe; De Nanteuil, Guillaume Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 841 - 844

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Citation Number: 26

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of thieno[3,2-b]pyrroloazepinones derivatives related to Hymenialdisine were prepared and tested for CHK1 inhibitory activity. Nanomolar inhibitions were achieved when electron-withdrawing substituents were introduced at position 3 of the thiophene ring.

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