Structure–activity relationship study of [1, 2, 3] thiadiazole necroptosis inhibitors

…, H Keys, A Jeevanandam, JA Porco, A Degterev…

Index: Teng, Xin; Keys, Heather; Jeevanandam, Arumugasamy; Porco Jr., John A.; Degterev, Alexei; Yuan, Junying; Cuny, Gregory D. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6836 - 6840

Full Text: HTML

Citation Number: 42

Abstract

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1, 2, 3] thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure–activity relationship study revealed that small ...

Related Articles:

Enantioselective construction of dialkylcarbinols: synthesis of (-)-5-hexadecanolide

[Taber,D.F.; Deker,P.B.; Gaul,M.D. Journal of the American Chemical Society, 1987 , vol. 109, p. 7488]

Enantioselective construction of dialkylcarbinols: synthesis of (-)-5-hexadecanolide

[Taber,D.F.; Deker,P.B.; Gaul,M.D. Journal of the American Chemical Society, 1987 , vol. 109, p. 7488]

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1, 4-naphthoquinones via one-pot aryne acyl-alkylation/condensation

[Allan, Kevin M.; Hong, Boram D.; Stoltz, Brian M. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 23 p. 4960 - 4964]

Highly Enantioselective Synthesis of β??Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β??Enamino Esters

[Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867]

Ring formation via β-keto ester dianions

[Sum,P.-E.; Weiler,L. Canadian Journal of Chemistry, 1977 , vol. 55, p. 996 - 1000]

More Articles...