A Simple Synthesis of Functionalized 3??Bromocoumarins by a One??Pot Three??Component Reaction

D Audisio, S Messaoudi, JD Brion…

Index: Audisio, Davide; Messaoudi, Samir; Brion, Jean-Daniel; Alami, Mouad European Journal of Organic Chemistry, 2010 , # 6 p. 1046 - 1051

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Citation Number: 22

Abstract

Abstract Functionalized 3-bromocoumarins 2 have been prepared by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene) acetate, N-bromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large ...

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