Tetrahedron Letters

A new access to efaroxan and its 5-amino derivatives

T Lomberget, R Barret

Index: Lomberget, Thierry; Barret, Roland Tetrahedron Letters, 2008 , vol. 49, # 4 p. 715 - 718

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Citation Number: 8

Abstract

The formal total synthesis of racemic efaroxan, a 2-disubstituted 2, 3-dihydrobenzofuran having interesting therapeutic properties, and the preparation of some 5-amino derivatives were achieved using a convergent approach. The key intermediates of both syntheses were obtained after a [3+ 2] cycloaddition reaction between two easily accessible partners.

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