Synthesis and biological evaluation of allenic quinazolines using palladium-catalyzed hydride-transfer reaction

H Nakamura, S Onagi

Index: Nakamura, Hiroyuki; Onagi, Shinya Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2539 - 2542

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Citation Number: 24

Abstract

Allenic quinazolines were designed as mimics of Tarceva, which is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and synthesized from the corresponding 4- (iodoanilino) quinazolines or 4-(iodophenoxy) quinazolines with N, N-dicyclohexylprop-2- ynylamine by the Sonogashira coupling followed by palladium-catalyzed hydride-transfer reaction. Cell growth inhibition of ward A431, Kato III, SKBR3, and HepG2 was examined. ...