Specific enolates from. alpha.-amino ketones

…, JN Bonfiglio, DA Grudoski, J Marks

Index: Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315

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Citation Number: 65

Abstract

NEe 1: 4gd 1: 2 1: o. o 2 d 1: 0.02 d, g 1: 0.02 d, ga Method A: The ketone was added to 1.1- 1.5 equiv of LDA in THF at-78" C. Method B: The ketone was added to 0.8 equiv of lithium hexamethyldisilazide at-78'C and equilibrated at 0 C. Method C: The ketone, 1.2 equiv of trialkylchlorosilane, 2.4 equiv of triethylamine, and DMF were heated at 80 o C for 48 h. The ratio given represents the limits of our detection. e Not examined. f Decomposition. g This ...