N-Trihalomethyl derivatives of benzimidazole, benzotriazole and indazole

…, KI Petko, VI Troitskaya, VI Rudyk, VV Rudyuk

Index: Yagupolskii, Lev M.; Fedyuk, Dmitrij V.; Petko, Kirill I.; Troitskaya, Valeriya I.; Rudyk, Valentina I.; Rudyuk, Vitalij V. Journal of Fluorine Chemistry, 2000 , vol. 106, # 2 p. 181 - 187

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Citation Number: 25

Abstract

1-Chlorodifluoromethyl-and 1-trifluoromethyl-substituted 2-methylbenzimidazoles and benzotriazoles were obtained by chlorination of the corresponding methyl 1- azoledithiocarboxylates and subsequent fluorination of the resulting 1-trichloromethyl derivatives. The condensation of N-sodium salts of 2-alkylbenzimidazoles and indazole with CF2Br2 was shown to afford the corresponding 1-bromodifluoromethylated compounds.