Chemistry–A European Journal

Total Syntheses of the Tylophora Alkaloids Cryptopleurine,(−)??Antofine,(−)??Tylophorine, and (−)??Ficuseptine C

A Fürstner, JWJ Kennedy

Index: Fuerstner, Alois; Kennedy, Jason W.J. Chemistry - A European Journal, 2006 , vol. 12, # 28 p. 7398 - 7410

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Citation Number: 141

Abstract

Abstract A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer cell lines. The advantages of the chosen route are illustrated by the total syntheses of the phenanthroquinolizidine cryptopleurine (1) and the phenanthroindolizidines (−)-antofine (2),(−)-tylophorine (3), and their only recently ...