Lysine sulfonamides as novel HIV-protease inhibitors: Nε-acyl aromatic α-amino acids

…, J Yelle, V Perron, N LeBerre, D Herbart, JJ Wu

Index: Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462

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Citation Number: 59

Abstract

A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor- resistant HIV viruses.