Bacteriostats. VI. 1a Bacteriostatic Activities of Some Substituted Guanidines1b

AF McKay, DL Garmaise, HA Baker…

Index: McKay,A.F. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 587 - 595

Full Text: HTML

Citation Number: 16

Abstract

Discus, sion The exact mode of action of these substituted biurets on inhibition of gastric secretion and incidence of ulcer formation is not clear. Various classes of compounds will inhibit these gastric parameters in the ligated rat (ie., anticholinergics, antispasmodics, carbonic anhydrase inhibitors, CNS depressants). While no data are available on possible inhibition of carbonic anhydrase, no evidence of diuresis (qualitative observed with ...