Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)

SY Chou, WK Yin, YS Chung, LS Chang…

Index: Chou, Shan-Yen; Yin, Wei-Kung; Chung, Yuh-Shan; Chang, Lien-Shange; Liu, Chin-Wei; Chen, Shyh-Fong; Shih, Kae-Shyang Organic Process Research and Development, 2002 , vol. 6, # 3 p. 273 - 278

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Citation Number: 3

Abstract

This work presents an improved eight-step process, leading to kilogram quantities of high- quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.

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