α-Substituted N-(sulfonamido) alkyl-β-aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists

…, NM Willard, DH Nepomuceno, SJ Wilson…

Index: Youngman, Mark A.; McNally, James J.; Lovenberg, Timothy W.; Reitz, Allen B.; Willard, Nicole M.; Nepomuceno, Diane H.; Wilson, Sandy J.; Crooke, Jeffrey J.; Rosenthal, Daniel; Vaidya, Anil H.; Dax, Scott L. Journal of Medicinal Chemistry, 2000 , vol. 43, # 3 p. 346 - 350

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Citation Number: 53

Abstract

Introduction. Neuropeptide Y (NPY), first isolated from porcine brain, 1 is a powerful stimulant of food intake. 2-5 In landmark studies by Stanley and Leibowitz, 4, 5 injection of 100 ng of NPY into the hypothalamic paraventricular nucleus of live rats caused satiated animals to overeat. A dose of 1 µg induced animals to consume, within 4 h, an amount of food approximately equivalent to the normal daily intake in an agematched, vehicle- ...