Large yet Flexible N??Heterocyclic Carbene Ligands for Palladium Catalysis

S Meiries, G Le Duc, A Chartoire…

Index: Meiries, Sebastien; Le Duc, Gaetan; Chartoire, Anthony; Collado, Alba; Speck, Klaus; Arachchige, Kasun S. Athukorala; Slawin, Alexandra M. Z.; Nolan, Steven P. Chemistry - A European Journal, 2013 , vol. 19, # 51 p. 17358 - 17368

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Citation Number: 38

Abstract

Abstract A straightforward and scalable eight-step synthesis of new N-heterocyclic carbenes (NHCs) has been developed from inexpensive and readily available 2-nitro-m-xylene. This process allows for the preparation of a novel class of NHCs coined ITent (“Tent” for “tentacular”) of which the well-known IMes (N, N′-bis (2, 4, 6-trimethylphenyl) imidazol-2- ylidene), IPr (N, N′-bis (2, 6-di (2-propyl) phenyl) imidazol-2-ylidene) and IPent (N, N′- ...

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