Enzymes in Organic Synthesis, 15.–Synthesis of Methyl (S)??(−)??2, 3??O??Isopropylideneglycerate by Enantioselective Enzyme??catalyzed Hydrolysis of Methyl (±)??2, 3?? …

H Schick, E Schrötter, M Szymanowski…

Index: Schick, Hans; Schroetter, Eberhard; Szymanowski, Matthias; Knoll, Alexander Liebigs Annalen der Chemie, 1993 , # 1 p. 103 - 104

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Abstract

Abstract In contrast to porcine pancreatic lipase (PPL), the serine proteases aP 41 and thermitase are suited as catalysts for the enantioselective ester hydrolysis of methyl (π)-2, 3- O-isopropyl-ideneglycerate (rac-1). These enzymes allow the preparation of methyl (S)-(−)- 2, 3-O-isopropylideneglycerate (1) with an enantiomeric excess of 84–87% in a yield of 19– 27% related to the starting racemate.