Synthesis of chiral peptide nucleic acids using Fmoc chemistry

Y Wu, JC Xu

Index: Wu, Yun; Xu, Jie-Cheng Tetrahedron, 2001 , vol. 57, # 38 p. 8107 - 8113

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Citation Number: 24

Abstract

A Fmoc-based synthesis of chiral PNAs is described. Chiral monomer backbones were efficiently prepared by reductive amination of N-Fmoc-protected l, d-alaninals with glycine esters and the subsequent acylation of free amines with thymine-1-ylacetic acid. The dimer