Syntheses and activities of new C10 β-turn peptidomimetics

…, M Pattarawarapan, S Roy, HU Saragovi…

Index: Lee, Hong Boon; Zaccaro, Maria Clara; Pattarawarapan, Mookda; Roy, Sudipta; Saragovi, H. Uri; Burgess, Kevin Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 701 - 713

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Citation Number: 39

Abstract

A program to identify small molecules that mimic or disrupt protein-protein interactions led us to design the peptidomimetics 1-3. Solid-phase syntheses of 1-3 were developed. The purities of the crude materials isolated from the resin tend to be highest for the S-and N- compounds 2 and 3 and better than in the corresponding syntheses of peptidomimetics A. The particular dipeptide units incorporated were chosen to correspond with the turn ...

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