Chemical Communications

Design of photocleavable lipids and their application in liposomal “uncorking”

B Chandra, S Mallik, DK Srivastava

Index: Chandra, Binita; Mallik, Sanku; Srivastava Chemical Communications, 2005 , # 24 p. 3021 - 3023

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Citation Number: 20

Abstract

In liposome mediated target-specific drug delivery systems, three features need to be taken into consideration: (i) appropriate coating of liposomes to circumvent their clearance by the reticuloendothelial system (RES), 3 (ii) attachment of the target-specific recognition moiety (e.g., antibodies, receptor agonist/antagonist), and (iii) incorporation of the triggering mechanism. 1 Attachment of receptor-specific ligands ensures their adhesions to target cell surfaces. 1,4 Although the ...

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