Organic Process Research & Development

Renaissance of traditional organic reactions under microfluidic conditions: a new paradigm for natural products synthesis

K Tanaka, K Fukase

Index: Tanaka, Katsunori; Fukase, Koichi Organic Process Research and Development, 2009 , vol. 13, # 5 p. 983 - 990

Full Text: HTML

Citation Number: 36

Abstract

Continuous flow synthesis for bioactive natural products is described. Efficient procedures using the microfluidic system were developed for the large-scale synthesis of important synthetic units of asparagine-linked oligosaccharide in glycoprotein. Advantageous aspects of microfluidic conditions, ie, efficient mixing, fast heat transfer, and residence time control led to cation-mediated reactions, such as α-sialylation, β-mannosylation, and reductive ...