Oxidative Metabolism of Dihydrocodeine in Dark??Agouti and Sprague??Dawley Rat Liver Microsomes

LC Kirkwood, RL Nation, GD Reynolds…

Index: Kirkwood; Nation; Reynolds; Somogyi; Sansom Pharmaceutical Sciences, 1996 , vol. 2, # 6 p. 299 - 303

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Abstract

Abstract The oxidative metabolism of dihydrocodeine to nordihydrocodeine and dihydromorphine was studied in liver microsomes of female Dark-Agouti (cytochrome P450 2D1 (CYP2D1) deficient) and Sprague-Dawley rats. Evaluation of microsomal metabolism in these two rat strains is a useful in-vitro model to test possible substrates of polymorphic human cytochrome P450 2D6 (CYP2D6).