Absolute configuration of 6-methyl-5, 6, 7, 8-tetrahydropterin produced by enzymic reduction (dihydrofolate reductase and NADPH) of 6-methyl-7, 8-dihydropterin

WLF Armarego, P Waring, JW Williams

Index: Armarego, Wilfred L. F.; Waring, Paul; Williams, Jeffrey W. Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 334 - 336

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Citation Number: 15

Abstract

Dihydrofolate reductase (5, 6, 7, 8-tetrahydrofolate: NADP oxidoreductase, EC 1.5. 1.3.) and NADPH, which catalyse the reduction of 7, 8-dihydrofolic acid () stereospecifically to give one diastereoisomer of 5, 6, 7, 8-tetrahydrofolic acid (), also catalyse the reduction of 6- methyl-7, 8-dihydropterin () stereospecifically