Synthesis of an α-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-l-Homocysteine Hydrolase

JA Steere, PB Sampson, JF Honek

Index: Steere, Jennifer A.; Sampson, Peter B.; Honek, John F. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 457 - 460

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Citation Number: 38

Abstract

A phosphonic acid analogue of S-adenosyl-l-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-l-homocysteine hydrolase, however each presented distinct kinetic characteristics.