Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl) aminobenzophenones as open-ring derivatives of …

K Hirai, T Ishiba, H Sugimoto, T Fujishita…

Index: Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27

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Citation Number: 15

Abstract

Peptidoaminobenzophenones (l), terminal N-substituted peptidoaminobenzophenones (14), and acylglycylaminobenzophenones (16) were prepared as a novel series of ring-opened derivatives of 1, 4-benzodiazepine. Z-Gly-and Z-Ala-N-methylaminobenzophenones (4) were treated with HBr-HOAc to give Gly-and Ala-N-methylaminobenzophenone hydrobromides (8). Reaction of 8 with chloroacetyl chloride in dimethylformamide (DMF) ...