Synthesis and antiviral activity of 4, 6-disubstituted pyrimido [4, 5-b] indole ribonucleosides

M Tichý, R Pohl, HY Xu, YL Chen, F Yokokawa…

Index: Tichy, Michal; Pohl, Radek; Hocek, Michal; Xu, Hao Ying; Chen, Yen-Liang; Yokokawa, Fumiaki; Shi, Pei-Yong Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6123 - 6133,11

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Citation Number: 11

Abstract

A series of new pyrimido [4, 5-b] indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4, 6-dichloropyrimido [4, 5-b] indole ribonucleoside with (het) arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4, ...