Protein structure-based design, synthesis, and biological evaluation of 5-thia-2, 6-diamino-4 (3 H)-oxopyrimidines: Potent inhibitors of glycinamide ribonucleotide …

MD Varney, CL Palmer, WH Romines…

Index: Journal of Medicinal Chemistry, , vol. 40, # 16 p. 2502 - 2524

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Citation Number: 42

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Shown in Scheme 1 is the general strategy for the synthesis of the monocyclic 5-thiapyrimidinones 5−13. The key reaction in the sequence is the base-initiated coupling of ...

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