Rhodium catalyzed hydroformylation of 1, 1-bis (p-fluorophenyl) allyl or propargyl alcohol: a key step in the synthesis of Fluspirilen and Penfluridol

C Botteghi, M Marchetti, S Paganelli, F Persi-Paoli

Index: Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637

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Citation Number: 23

Abstract

Fluspirilen (1) and Penfluridol (2), two neuroleptic agents, belong to a wide class of pharmaceuticals that contain in their molecules a 4, 4-bis (p-fluorophenyl) butyl group bound to a nitrogen atom of a pyrrolidine, piperidine or piperazine moiety. A key intermediate for the synthesis of compounds 1 and 2, 4, 4-bis (p-fluorophenyl) butylbromide (15), has been prepared starting from commercially available 4, 4′-difluorobenzophenone (7) following ...