Nitrile-promoted Rh-catalyzed intermolecular hydroacylation of olefins with salicylaldehyde

…, S Nagumo, N Kawahara, H Suemune

Index: Imai, Masanori; Tanaka, Masakazu; Nagumo, Shinji; Kawahara, Norio; Suemune, Hiroshi Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2543 - 2546

Full Text: HTML

Citation Number: 36

Abstract

Rh-catalyzed intermolecular hydroacylation between salicylaldehyde and alkenylnitriles proceeded at room temperature to preferentially give normal-hydroacylated products. Addition of CH3CN and NaOAc accelerated the Rh-catalyzed hydroacylation of monoolefins to exclusively produce the normal-hydroacylated products under mild reaction conditions. Plausible mechanisms for the regioselections are also described.

Related Articles:

Heterocyclic amides: Inhibitors of acyl-CoA: cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the …

[O'Brien; Sliskovic; Picard; Lee; Purchase II; Roth; White; Anderson; Mueller; Bocan; Bousley; Hamelehle; Homan; Krause; Reindel; Stanfield; Turluck Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2354 - 2366]

Chemical defense and self-defense: Biochemical transformations of contact insecticides produced by soldier termites

[Spanton,S.G.; Prestwich,G.D. Tetrahedron, 1982 , vol. 38, p. 1921]

Chemical defense and self-defense: Biochemical transformations of contact insecticides produced by soldier termites

[Spanton,S.G.; Prestwich,G.D. Tetrahedron, 1982 , vol. 38, p. 1921]

A simple one-pot synthesis of nitriles from alcohols

[Camps, F.; Gasol, V.; Guerrero, A. Synthetic Communications, 1988 , vol. 18, # 4 p. 445 - 452]

More Articles...