Synthesis and substance P antagonist activity of naphthimidazolium derivatives

KB Lawrence, BR Venepalli, KC Appell…

Index: Lawrence; Venepalli; Appell; Goswami; Logan; Tomczuk; Yanni Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1273 - 1279

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Citation Number: 17

Abstract

Substance P (SP) is an undecapeptide neurotransmitter and is implicated in several important disease states, particularly in pain and inflammation.'P2 However, the therapeutic significance of a SP antagonist has not been fuuy explored, primarily due to the lack of orally available, nonpeptide SP antagonists except for the recently disclosed nonpeptidic quinuclidines. 3 During ongoing efforts to discover novel, nonpeptide SP antagonists, we ...