Synthesis, transformations, and biological properties of 7, 8-disubstituted xanthines

…, NM Nazinov, NV Chvalyuk, DN Lazareva

Index: Strokin, Yu. V.; Zarudii, F. S.; Kremzer, A. A.; Nazinov, N. M.; Chvalyuk, N. V.; Lazareva, D. N. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 5 p. 338 - 341 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 5 p. 566 - 569

Full Text: HTML

Citation Number: 1

Abstract

7-(2, 3-Dihydroxypropyl)-8-bromotheophylline (II) was obtained by the reaction of 8- bromotheophylllne (I) with glycidol in the presence of catalytic quantities of pyridine. The previously described [3, 8] 6, 8-dimethyl-2-hydroxymethyloxazolino [3, 2-f] xanthine (III) was obtained by the action of an equimolar amount of an alcoholic solution of alkali on the dihydroxy derivative II.