Tetrahedron letters

Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1, 2, 4-triazol-1-yl) propan-2-ols as antifungal agents

…, F Giraud, T Corbin, YM Na, G Le Baut, P Marchand…

Index: Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483

Full Text: HTML

Citation Number: 31

Abstract

New conazole antifungals, in the series of triazole alcohols 23a–d and 24a–e incorporating an indole moiety substituted at 5-position by halogens, a cyano or 4-methoxyphenyl group, have been synthesized by ring opening of corresponding oxiranes 15 and 16. These dihalogeno intermediates and their congeneers could be prepared in high yields by Corey– Chaykovsky reaction under microwave irradiation.

Related Articles:

… with 1??functionally substituted alkyl azoles: Novel synthesis of functionally substituted azolylbenzimidazoles and functionally substituted azolyl??1, 2, 4??triazoles

[Abdel-Megid, Mohamed; Elnagdi, Mohamed H.; Negm, Abdalla M. Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 105 - 108]

An investigation into the alkylation of 1, 2, 4-triazole

[Bulger, Paul G.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf-H. Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1297 - 1301]

Synthesis of 1-alkyl-1, 2, 4-triazoles: a new one-pot regiospecific procedure

[Astleford, Bret A.; Goe, Gerald L.; Keay, James G.; Scriven, Eric F. V. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 731 - 732]

Anti-Plasmodium activity of imidazolium and triazolium salts

[Vlahakis, Jason Z.; Lazar, Carmen; Crandall, Ian E.; Szarek, Walter A. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 6184 - 6196]

Regiospecific synthesis of 1-substituted 1, 2, 4-triazoles involving isomerization of the corresponding 4-substituted compounds.

[Smith, Keith; Small, Andrew; Hutchings, Michael G. Chemistry Letters, 1990 , # 3 p. 347 - 350]

More Articles...