Alkyne Metathesis: Development of a Novel Molybdenum??Based Catalyst System and Its Application to the Total Synthesis of Epothilone A and C

…, C Mathes, CW Lehmann

Index: Fuerstner, Alois; Mathes, Christian; Lehmann, Christian W. Chemistry - A European Journal, 2001 , vol. 7, # 24 p. 5299 - 5317

Full Text: HTML

Citation Number: 218

Abstract

Abstract Sterically hindered molybdenum (III) amido complexes of the general type [Mo {(tBu)(Ar) N} 3](1), upon treatment with CH 2 Cl 2 or other halogen donors, have been converted into highly effective catalysts for all kinds of alkyne metathesis reactions. Although the actual nature of the propagating species formed in situ is still elusive, halogen transfer to the Mo center of 1 plays a decisive role in the activation of such precatalysts. It was ...

Related Articles:

Total synthesis of epothilone A: the macrolactonization approach

[Yang; He; Vourloumis; Vallberg; Nicolau Angewandte Chemie - International Edition in English, 1997 , vol. 36, # 1-2 p. 166 - 168]

Enantioselective total synthesis of epothilones A and B using multifunctional asymmetric catalysis

[Sawada, Daisuke; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2000 , vol. 122, # 43 p. 10521 - 10532]

Enantioselective total synthesis of epothilones A and B using multifunctional asymmetric catalysis

[Sawada, Daisuke; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2000 , vol. 122, # 43 p. 10521 - 10532]

Total syntheses of epothilones A and B

[Dongfang, Meng; Bertinato, Peter; Balog, Aaron; Su, Dai-Shi; Kamenecka, Ted; et al. Journal of the American Chemical Society, 1997 , vol. 119, # 42 p. 10073 - 10092]

Total syntheses of epothilones A and B

[Dongfang, Meng; Bertinato, Peter; Balog, Aaron; Su, Dai-Shi; Kamenecka, Ted; et al. Journal of the American Chemical Society, 1997 , vol. 119, # 42 p. 10073 - 10092]

More Articles...