Tetrahedron letters

Microwave enhanced greener synthesis of indazoles via nitrenes

DJ Varughese, MS Manhas, AK Bose

Index: Varughese, Deepu John; Manhas, Maghar S.; Bose, Ajay K. Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6795 - 6797

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Citation Number: 49

Abstract

Non-traditional methods (grinding, water-based biphasic reactions, microwave chemistry) were used for the preparation of Schiff bases from several amines and 2- nitrobenzaldehydes. These nitro compounds were allowed to react with triethyl phosphite under microwave irradiation for the generation of nitrenes that underwent insertion reactions to form indazoles. This procedure constitutes an energy-efficient, greener chemistry ...

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