β 3-Adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-{[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl] amino} …

…, H Mukaiyama, A Hirabayashi, H Muranaka…

Index: Tanaka; Tamai; Mukaiyama; Hirabayashi; Muranaka; Ishikawa; Akahane Bioorganic and medicinal chemistry, 2001 , vol. 9, # 12 p. 3265 - 3271

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Citation Number: 17

Abstract

In a search for novel analogues of β3-adrenoceptor (AR) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-{[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1- methylethyl] amino} ethyl) phenoxy]-2-methylpropionic acids (1a–e), into which a fibrate-like structure had been incorporated, were synthesised. Compound 1a was found to be a selective β3-AR agonist in functional assays using the ferret detrusor (β3-AR), rat uterus ( ...