Development of a scalable synthesis of GSK183390A, a PPAR α/γ agonist

…, SC Shilcrat, RE Herrmann, DB Patience…

Index: Oh, Lynette M.; Wang, Huan; Shilcrat, Susan C.; Hermann, Robert E.; Patience, Daniel B.; Spoors, P. Grant; Sisko, Joseph Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1032 - 1042

Full Text: HTML

Citation Number: 13

Abstract

A scalable synthesis of GSK183390A, a PPAR α/γ agonist, is described. This synthesis is highlighted by (1) a regioselective formal 1, 3-dipolar cycloaddition reaction between an enamine and a nitrile imine dipole to form a 1, 3, 5-trisubstituted pyrazole and (2) a regioselective amidomethylation of an ο-cresol derivative using 2-chloro-N- hydroxymethylacetamide.

Related Articles:

β 3-Adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-{[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl] amino} …

[Tanaka; Tamai; Mukaiyama; Hirabayashi; Muranaka; Ishikawa; Akahane Bioorganic and medicinal chemistry, 2001 , vol. 9, # 12 p. 3265 - 3271]

More Articles...