Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6π-electrocyclization in water and application to natural products

EJ Jung, BH Park, YR Lee

Index: Jung, Ene Jin; Park, Byung Ho; Lee, Yong Rok Green Chemistry, 2010 , vol. 12, # 11 p. 2003 - 2011

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Citation Number: 56

Abstract

In water medium, environmentally benign, facile, and efficient synthesis of pyrans was achieved in good yields by the reactions of a variety of cyclic 1, 3-dicarbonyls with several α, β-unsaturated aldehydes. The key strategy was a formal [3+ 3] cycloaddition by domino Knoevenagel/6π-electrocyclization. This methodology was applied to the synthesis of biologically interesting pyranocoumarin, pyranoquinolinone, and pyranonaphthoquinone ...