One??pot Synthesis of 2, 5??Disubstituted??1, 3, 4??oxadiazoles Based on the Reaction of N, N??Dimethyl Amides with Acid Hydrazides

…, Y Tao, D Xu, H Zhang, L Duan

Index: Li, Qiang; Tao, Yi; Xu, Dongfang; Zhang, Haobing; Duan, Liping Journal of the Chinese Chemical Society, 2014 , vol. 61, # 6 p. 665 - 670

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Abstract

Abstract Convenient and efficient one pot method for the synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazoles based on the reaction of N, N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N, N-dimethyl amides to 2, 5-disubstituted-1, 3, 4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis.

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